This article is from the Your New Puppy FAQ, by Cindy Tittle Moore with numerous contributions by others.
Newborn puppies receive immunization against diseases from colostrum
contained in their mothers milk while nursing (assuming the bitch was
properly vaccinated shortly before the breeding took place).
Initially, during their first 24 hours of life, maternal antigens
(passive immunity) are absorbed through the pups intestines which are
very, very thin during those first few hours (this is why it is so
important that puppies nurse from the mother during that critical
time). After the colostrum ceases (a day or so later), the maternal
antigens decline steadily.
During this time, puppies cannot build up their own natural immunity
because the passive immunity gets in the way. As the passive immunity
gradually declines, the pup's immune system takes over. At this time,
the pups should be given their first immunization shots so they can
build up their own antibodies against them. However, there is no way
to tell when passive immunity is gone. This is why pups should be
given a shot every few weeks (2 - 3 weeks apart and a series of at
LEAST three shots).
Picture a plot of antibody level versus time. Maternal antibody is
steadily declining. You just don't know the rate. At some level, say
X, protection from parvo is sufficient. Below X, protection may be
less than effective against an infection. In general, vaccine antigen
cannot stimulate the puppy's own immune system until the maternal
antibody level is below X. Let's say it is .7*X. Here's the rub. The
antibody level spends some time dropping from X to .7X. During this
time, even if you vaccinated every day, you would (in this theoretical
discussion) not be able to stimulate immunity. Yet you are below that
level of maternal protection at which infection can be effectively
fought off.
Thus the importance of giving several vaccinations at 2-4 week
intervals until around 16-18 weeks. One maximizes the chance of
catching the puppy's immune system as soon as it is ready to respond,
minimizing the amount of time the puppy may be susceptible to
infection.
IMPORTANT: The last shot should be given AFTER 16 weeks of age (4
months) to be SURE that dam's antibodies have not gotten in the way of
the pup building up its own immunity (read the label of the vaccine!).
Up until 8 weeks or so, the shots should consist of Distemper,
Measles, and CPI. After that, it should be DHLPP (Distemper,
Hepatitis, Leptospirosis, Parainfluenza and Parvovirus). This is at
minimum: you may need to add other vaccinations appropriate to your
area, such as Lyme, Heartworm (actually a preventive medicine), Rabies
(most places), and so on.
You should keep your puppy away from all strange dogs. If you know
that a particular dog is current on its shots and not carrying
disease, then go ahead and let your puppy socialize. The same holds
true for people. Ask them to wash their hands before they play with
your puppy. It can't hurt and it could save you a great deal of grief.
As your puppy gets its shots, you can slowly add more and more
exposure to its life. But keep in mind this is an infant and needs
gentle care!
Worms can present a serious problem to puppy health. There is no good
way to prevent puppies from having worms, for a variety of reasons.
You should take your puppy in regularly for worm-testing. Worms can
interfere with the puppy's growth if left unchecked. Since it is very
common for puppies (even from the best breeder) to have worms from the
dam's dormant worms, you must take care to have your puppy checked
regularly when young.
 
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