Description

This article is from the Interpretation Of Lab Test Profiles, by Ed Uthman uthman@neosoft.com with numerous contributions by others.

24 Drugs known to cause hepatocellular damage include the following:

    acetaminophen     allopurinol     aminosalicylic acid  amitriptyline
    androgens         asparaginase    aspirin              azathioprine
    carbamazepine     chlorambucil    chloramphenicol      chlorpropamide
    dantrolene        disulfiram      estrogens            ethanol
    ethionamide       halothane       ibuprofen            indomethacin
    iron salts        isoniazid       MAO inhibitors       mercaptopurine
    methotrexate      methoxyflurane  methyldopa           mithramycin
    nicotinic acid    nitrofurantoin  oral contraceptives  papaverine
    paramethadione    penicillin      phenobarbital        phenazopyridine
    phenylbutazone    phenytoin       probenecid           procainamide
    propylthiouracil  pyrazinamide    quinidine            sulfonamides
    tetracyclines     trimethadione   valproic acid

Disproportionate elevation of direct (conjugated) bilirubin is
seen in cholestasis and late in the course of chronic liver
disease. Indirect (unconjugated) bilirubin tends to predominate
in hemolysis and Gilbert's disease.

Decreased serum total bilirubin is probably not of clinical
significance but has been observed in iron deficiency anemia.

 

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